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4-Choice Gambling Task (4C-GT) for Mice

Brand: Campden

Product Code: 89550A

Based on the Iowa Gambling Task, the rodent chooses from four illuminated windows. A touch in any of the windows will result in either a Win (food reward is delivered) or a Loss (timeout period with no reward). Each window is associated with a different amount of reward. The larger the associated reward, the lower the probability of receiving a Win and the longer the timeout if the trial results in a Loss. The subject must learn to avoid the high-risk, high-reward options in order to maximize earnings. The test is sensitive to serotonergic and dopaminergic agents.

Features:

A test of impulsivity and decision making
All training paradigms and advice included

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Example Neural Systems Involved

Dopamine
Serotonin

Clinical Areas Showing Impairment

Bipolar Disorder
Gambling
Depression
OCD
ADHD
Parkinson’s
Schizophrenia

Cognitive Functions Covered

Impulsivity
Decision making

Typical Training Times (depends on strain and age)

1-2 weeks to train to touch the screen and initiate the task
4 sessions familiarizing with choices available
~13 sessions testing

Scientific Resources

Openshaw, R. L., Pratt, J. A., & Morris, B. J. (2022). The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task. Disease Models & Mechanisms, 15(3). - Abstract
Humby, T., Smith, G. E., Small, R., Davies, W., Carter, J., Bentley, C. A., Winstanley, C. A., Rogers, R. D., & Wilkinson, L. S. (2020). Effects of 5-HT 2C, 5-HT 1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology, 237(6), 1745?1756. - Abstract
Cho, B. R., Kwak, M. J., Kim, W. Y., & Kim, J. H. (2018). Impulsive action and impulsive choice are differentially expressed in rats depending on the age at exposure to a gambling task. Frontiers in Psychiatry, 9(OCT), 503. - Abstract
Coba MP, Komiyama NH, Nithianantharajah J, et al. (2012) TNiK is required for postsynaptic and nuclear signalling pathways and cognitive function. J Neurosci.; 32(40):13987-13999.