Example Neural Systems Involved

  • Infralimbic Cortex
  • Striatum
  • AmygdalaPerirhinal Cortex

Clinical Areas Showing Impairment

  • ADHD
  • OCD

Cognitive Functions Covered

  • Cognitive Flexibility and Response Inhibition
  • Executive Function

Typical Training Times (depends on strain and age)

  • Approximately 4 sessions training plus a few extinction sessions

Scientific Resources

  • Kljakic, O., Jan?čkov?, H., Skirzewski, M., Reichelt, A., Memar, S., Mestikawy, S. El, Li, Y., Saksida, L. M., Bussey, T. J., Prado, V. F., & Prado, M. A. M. (2022). Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons. The FASEB Journal, 36(2), e22135. - Abstract
  • Luo, J., Tan, J., & Nithianantharajah, J. (2020). Associative Learning and Motivation Differentially Requires Neuroligin-1 at Excitatory Synapses. BioRxiv, 2020.01.01.890798. - Abstract
  • Kim, E., White, M. A., Phillips, B. U., Lopez-Cruz, L., Kim, H., Heath, C. J., Lee, J. E., Saksida, L. M., Sreedharan, J., & Bussey, T. J. (2020). Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD. Translational Psychiatry, 10(1). - Abstract
  • Lim, J., Kim, E., Noh, H. J., Kang, S., Phillips, B. U., Kim, D. G., Bussey, T. J., Saksida, L., Heath, C. J., & Kim, C. H. (2019). Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses. Molecular Brain, 12(1). - Abstract
  • Dam, S. A., Jager, A., Oomen, C. A., Buitelaar, J. K., Arias-Vasquez, A., & Glennon, J. C. (2019). Inhibitory control in BALB/c mice sub-strains during extinction learning. European Neuropsychopharmacology, 29(4), 509-518. - Abstract
  • Cho, B. R., Kwak, M. J., Kim, W. Y., & Kim, J. H. (2018). Impulsive action and impulsive choice are differentially expressed in rats depending on the age at exposure to a gambling task. Frontiers in Psychiatry, 9(OCT), 503. - Abstract
  • Brigman, J. L., Feyder, M., Saksida, L. M., Bussey, T. J., Mishina, M., & Holmes, A. (2008). Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit. Learning & Memory (Cold Spring Harbor, N.Y.), 15(2), 50-54. - Abstract

Required Accessories

Second Generation Bussey-Saksida Touch Screen Chamber for Rats

The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.

Brand: Campden
Model: 80604A
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