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5/9 Serial Reaction Task

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Location Discrimination (LD) for Rats

Brand: Campden

Product Code: 89546A-R

The rodents are required to discriminate between two white squares on the screen. Responses to squares on one side of the screen will be rewarded, while responses on the other side of the screen will be punished with a time out period. The distance between the two squares is varied from trial to trial. Animals with lesions in the dorsal hippocampus were impaired when the locations were close together, but not when they were far apart. Once 7 out of 8 trials are responded to correctly, the correct side is reversed, adding a reversal learning component. It is sensitive to hippocampal lesions and associated with glutamate receptor regulation and signaling.

Features:

A spatial memory task with a reversal learning component.
All training paradigms and advice included
Use flexi-shelf in rat chamber for improved performance (reduces impulsive responses from the rat)

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Example Neural Systems Involved

Hippocampus
Neurogenesis

Clinical Areas Showing Impairment

Schizophrenia
Alzheimers’s

Cognitive Functions Covered

Learning and Memory
Location Discrimination / Pattern Separation

Typical Training Times (depends on strain and age)

1-2 weeks to train to touch the screen and initiate the task
10-20 sessions

Mouse

A mouse performing the Location Discrimination for Rodents (LD), using the bottom 6 windows in the 12 window mask.

Scientific Resources

Palmer, D., Dumont, J. R., Dexter, T. D., Prado, M. A. M., Finger, E., Bussey, T. J., & Saksida, L. M. (2021). Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease. In Neurobiology of Learning and Memory (Vol. 182, p. 107443). - Abstract
Yoo, S., Stremlau, M., Pinto, A., Woo, H., van Praag, H., & Curtis, O. (2021). Effects of combined anti-hypertensive and statin treatment on memory, fear extinction, adult neurogenesis, and angiogenesis in adult and middle-aged mice. Cells, 10(7), 1778. - Abstract
Trammell, T. S., Henderson, N. L., Madkour, H. S., Stanwood, G. D., & Graham, D. L. (2020). GLP-1R activation alters performance in cognitive tasks in a sex-dependent manner. Neurological Sciences. - Abstract

Product Resources

Videos

Location Discrimination for Rodents (LD)