Sleep Fragmentation Bar

The cycle time selector includes a variety of different cycle times.  The continuous sweep setting now takes just 7.5 seconds.  Selectable inter-sweep cycle values start at 0.25 minutes (15 seconds) all the way up to 30 minutes.  Alternately, sweeps may be initiated from a remote device.

Specifications:

Power Supply

  • 9 VDC @ 2A center positive supply (included)

Cycle Times

  • Continuous: Approximately 7.5 seconds
  • Selectable (min): 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 10, 15, 20, 25, 30

External Initiate / Event Output

  • General: 2.5mm connection, 3 conductor
  • Base: Ground
  • Ring: Event Out - Open collector, Pull up if needed (30 VDC max)
  • Tip: Ext Initiate, active low switch closure

Dimensions

  • Outside: 16.0”L x 10.5”W x 14.5” H (40.6 x 26.7 x 36.8 cm)
  • Inside Living Space: 9.24”L x 7.49”W x 7.52”H (23.5 x 19.0 x 19.1 cm)
  • Weight: 12 lbs (5.4 kilograms)

Scientific Resources

  • Blackwell, A. A., Tracz, J. A., Fesshaye, A. S., Tidmore, A., Osterlund Oltmanns, J. R., Schaeffer, E. A., Lake, R. I., Wallace, D. G., & Britten, R. A. (2023). Fine motor deficits exhibited in rat string-pulling behavior following exposure to sleep fragmentation and deep space radiation. Experimental Brain Research, 241(2), 427-440. Read More
  • Nguyen, V. T., Fields, C. J., & Ashley, N. T. (2023). Temporal dynamics of pro-inflammatory cytokines and serum corticosterone following acute sleep fragmentation in male mice. PLOS ONE, 18(12), e0288889. Read More
  • Puech, C., Badran, M., Barrow, M. B., Runion, A. R., & Gozal, D. (2023). Solriamfetol improves chronic sleep fragmentation-induced increases in sleep propensity and ameliorates explicit memory in male mice. SLEEP, 46(5). Read More
  • Puech, C., Badran, M., Runion, A. R., Barrow, M. B., Cataldo, K., & Gozal, D. (2023). Cognitive Impairments, Neuroinflammation and Blood-Brain Barrier Permeability in Mice Exposed to Chronic Sleep Fragmentation during the Daylight Period. International Journal of Molecular Sciences, 24(12), 9880. Read More
  • Wang, C., Nambiar, A., Strickland, M. R., Lee, C., Parhizkar, S., Moore, A. C., Musiek, E. S., Ulrich, J. D., & Holtzman, D. M. (2023). APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading. Journal of Clinical Investigation, 133(14). Read More
  • Ensminger, D. C., Wheeler, N. D., al Makki, R., Eads, K. N., & Ashley, N. T. (2022). Contrasting effects of sleep fragmentation and angiotensin-II treatment upon pro-inflammatory responses of mice. Scientific Reports, 12(1), 14763. Read More
  • Guo, L., Reed, K. M., Carter, A., Cheng, Y., Roodsari, S. K., Martinez Pineda, D., Wellman, L. L., Sanford, L. D., & Guo, M.-L. (2022). Sleep-Disturbance-Induced Microglial Activation Involves CRH-Mediated Galectin 3 and Autophagy Dysregulation. Cells, 12(1), 160. Read More
  • Heyde, A., Rohde, D., McAlpine, C. S., Zhang, S., Hoyer, F. F., Gerold, J. M., Cheek, D., Iwamoto, Y., Schloss, M. J., Vandoorne, K., Iborra-Egea, O., Mu?oz-Guijosa, C., Bayes-Genis, A., Reiter, J. G., Craig, M., Swirski, F. K., Nahrendorf, M., Nowak, M. A., & Naxerova, K. (2021). Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell, 184(5), 1348-1361.e22. Read More
  • Mishra, I., Pullum, K. B., Thayer, D. C., Plummer, E. R., Conkright, B. W., Morris, A. J., O'Hara, B. F., Demas, G. E., & Ashley, N. T. (2020). Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 318(4), R781-R789. Read More
  • McAlpine, C. S., Kiss, M. G., Rattik, S., He, S., Vassalli, A., Valet, C., Anzai, A., Chan, C. T., Mindur, J. E., Kahles, F., Poller, W. C., Frodermann, V., Fenn, A. M., Gregory, A. F., Halle, L., Iwamoto, Y., Hoyer, F. F., Binder, C. J., Libby, P., ... Swirski, F. K. (2019). Sleep modulates haematopoiesis and protects against atherosclerosis. Nature, 566(7744), 383-387. Read More
  • McLain, J. M., Alami, W. H., Glovak, Z. T., Cooley, C. R., Burke, S. J., Collier, J. J., Baghdoyan, H. A., Karlstad, M. D., & Lydic, R. (2018). Sleep fragmentation delays wound healing in a mouse model of type 2 diabetes. Sleep. Read More
  • Chopra, S., Polotsky, V. Y., & Jun, J. C. (2016). Sleep Apnea Research in Animals. Past, Present, and Future. American Journal of Respiratory Cell and Molecular Biology, 54(3), 299-305. Read More
  • Cortese, R., Khalyfa, A., Bao, R., Andrade, J., & Gozal, D. (2015). Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation. International Journal of Obesity, 39(7), 1135-1142. Read More
  • Dumaine, J. E., & Ashley, N. T. (2015). Acute sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone concentration. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 308(12), R1062-R1069. Read More
  • Mutskov, V., Khalyfa, A., Wang, Y., Carreras, A., Nobrega, M. A., & Gozal, D. (2015). Early-life physical activity reverses metabolic and Foxo1 epigenetic misregulation induced by gestational sleep disturbance. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 308(5), R419-R430. Read More
  • Zheng, J., Almendros, I., Wang, Y., Zhang, S. X., Carreras, A., Qiao, Z., & Gozal, D. (2015). Reduced NADPH oxidase type 2 activity mediates sleep fragmentation-induced effects on TC1 tumors in mice. OncoImmunology, 4(2), e976057. Read More
  • Wang, Y., Carreras, A., Lee, S., Hakim, F., Zhang, S. X., Nair, D., Ye, H., & Gozal, D. (2014). Chronic sleep fragmentation promotes obesity in young adult mice. Obesity, 22(3), 758-762. Read More
  • Zhang, S. X. L., Khalyfa, A., Wang, Y., Carreras, A., Hakim, F., Neel, B. A., Brady, M. J., Qiao, Z., Hirotsu, C., & Gozal, D. (2014). Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice. International Journal of Obesity, 38(4), 619-624. Read More
  • Gharib, S. A., Khalyfa, A., Abdelkarim, A., Bhushan, B., & Gozal, D. (2012). Integrative miRNA-mRNA profiling of adipose tissue unravels transcriptional circuits induced by sleep fragmentation. PloS One, 7(5), e37669. Read More
  • Kaushal, N., Nair, D., Gozal, D., & Ramesh, V. (2012). Socially isolated mice exhibit a blunted homeostatic sleep response to acute sleep deprivation compared to socially paired mice. Brain Research, 1454, 65-79. Read More
  • Kaushal, N., Ramesh, V., & Gozal, D. (2012a). Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 303(1), R19-R29. Read More
  • Kaushal, N., Ramesh, V., & Gozal, D. (2012b). TNF-α and Temporal Changes in Sleep Architecture in Mice Exposed to Sleep Fragmentation. PLoS ONE, 7(9), e45610. Read More
  • Ramesh, V., Nair, D., Zhang, S. X. L., Hakim, F., Kaushal, N., Kayali, F., Wang, Y., Li, R. C., Carreras, A., & Gozal, D. (2012). Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway. Journal of Neuroinflammation, 9(1), 601. Read More
  • Nair, D., Zhang, S. X. L., Ramesh, V., Hakim, F., Kaushal, N., Wang, Y., & Gozal, D. (2011). Sleep Fragmentation Induces Cognitive Deficits Via Nicotinamide Adenine Dinucleotide Phosphate Oxidase-dependent Pathways in Mouse. American Journal of Respiratory and Critical Care Medicine, 184(11), 1305-1312. Read More