Example Neural Systems Involved
- Dopamine
Clinical Areas Showing Impairment
- Huntington’s
- Schizophrenia
Cognitive Functions Covered
- Motivation
- Decision making
Typical Training Times (depends on strain and age)
- About 16 sessions from first habituation to reach stable PR performance
Scientific Resources
- Kljakic, O., Janíčková, H., Skirzewski, M., Reichelt, A., Memar, S., Mestikawy, S. El, Li, Y., Saksida, L. M., Bussey, T. J., Prado, V. F., & Prado, M. A. M. (2022). Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons. The FASEB Journal, 36(2), e22135. - Abstract
- DeBrosse, A. C., Wheeler, A. M., Barrow, J. C., & Carr, G. V. (2020). Inhibition of Catechol-O-methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice. Frontiers in Behavioral Neuroscience, 14. - Abstract
- Kim, E., White, M. A., Phillips, B. U., Lopez-Cruz, L., Kim, H., Heath, C. J., Lee, J. E., Saksida, L. M., Sreedharan, J., & Bussey, T. J. (2020). Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS–FTD. Translational Psychiatry, 10(1). - Abstract
- Hailwood, J. M., Heath, C. J., Phillips, B. U., Robbins, T. W., Saksida, L. M., & Bussey, T. J. (2019). Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation. Neuropsychopharmacology, 44(6), 1068–1075. - Abstract
- Heath, C. J., O’Callaghan, C., Mason, S. L., Phillips, B. U., Saksida, L. M., Robbins, T. W., Barker, R. A., Bussey, T. J., & Sahakian, B. J. (2019). A Touchscreen Motivation Assessment Evaluated in Huntington’s Disease Patients and R6/1 Model Mice. Frontiers in Neurology, 10. - Abstract
- Lim, J., Kim, E., Noh, H. J., Kang, S., Phillips, B. U., Kim, D. G., Bussey, T. J., Saksida, L., Heath, C. J., & Kim, C. H. (2019). Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses. Molecular Brain, 12(1). - Abstract
- Hailwood, J. M., Heath, C. J., Robbins, T. W., Saksida, L. M., & Bussey, T. J. (2018). Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats. Psychopharmacology, 235(9), 2739–2753. - Abstract
- Kim, E. W., Phillips, B. U., Heath, C. J., Cho, S. Y., Kim, H., Sreedharan, J., Song, H. T., Lee, J. E., Bussey, T. J., Kim, C. H., Kim, E., & Saksida, L. M. (2017). Optimizing reproducibility of operant testing through reinforcer standardization: Identification of key nutritional constituents determining reward strength in touchscreens. Molecular Brain, 10(1). - Abstract
- Heath, Christopher J.; Bussey, Timothy J; Saksida, L. M. (2015). Touchscreen Assessment of Motivation and Reinforcement-Related Choice Behaviour in Mice. Psychopharmacology, 232(21–22), 4043–4057. - Abstract
- Heath, C. J., Bussey, T. J., & Saksida, L. M. (2015). Motivational assessment of mice using the touchscreen operant testing system: Effects of dopaminergic drugs. Psychopharmacology, 232(21–22), 4043–4057. - Abstract
Product Resources
Required Accessories
Second Generation Bussey-Saksida Touch Screen Chamber for Rats
The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.
View DetailsRelated Products
Progressive Ratio and Effort Related Choice Task (PR/ERC) for Mice
Adapted for mice, this touch screen task has been shown equivalent to those performed with levers or nose-poke holes in measuring motivation and reward-related decision making.
View Details